Important Safety Information/Uses
Early Breast Cancer
KADCYLA is a prescription medicine used as an adjuvant (after surgery) treatment for HER2-positive early breast cancer when the patient has taken neoadjuvant (before surgery) treatment including a taxane and trastuzumab (Herceptin®) and there is cancer remaining in the tissue removed during surgery.
Patients are selected for therapy based on an FDA-approved test for KADCYLA.
Metastatic Breast Cancer
KADCYLA is a prescription medicine used to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic breast cancer) after prior treatment with trastuzumab (Herceptin®) and a taxane. Prior treatment could have been for the initial treatment of breast cancer or for the treatment of cancer that had spread to other parts of the body.
Patients are selected for therapy based on an FDA-approved test for KADCYLA.
What is the most Important Safety Information I should know about KADCYLA?
Liver problems
- KADCYLA may cause severe liver problems that can be life-threatening. Symptoms of liver problems may include vomiting, nausea, eating disorder (anorexia), yellowing of the skin (jaundice), stomach pain, dark urine, or itching
Heart problems
- KADCYLA may cause heart problems, including those without symptoms (such as reduced heart function) and those with symptoms (such as congestive heart failure). Symptoms may include swelling of the ankles or legs, shortness of breath, cough, rapid weight gain of more than 5 pounds in 24 hours, dizziness or loss of consciousness, or irregular heartbeat
Pregnancy
- Receiving KADCYLA during pregnancy can result in the death of an unborn baby and birth defects. Birth control should be used while you receive KADCYLA and for 7 months after your last dose of KADCYLA
- If you think you may be pregnant, you should contact your healthcare provider immediately
- If you are exposed to KADCYLA during pregnancy or if you become pregnant within 7 months following your last dose of KADCYLA, you are encouraged to report KADCYLA exposure to Genentech by calling1-888-835-2555
- If you are a male patient with a female partner that could become pregnant, birth control should be used during treatment and for 4 months following your last dose of KADCYLA
- You should not breastfeed during treatment and for 7 months after the last dose of KADCYLA
Contact your doctor right away if you experience symptoms associated with these side effects.
What are the additional possible serious side effects of KADCYLA?
Lung problems
- KADCYLA may cause lung problems, including inflammation of the lung tissue, which can be life-threatening. Signs of lung problems may include trouble breathing, cough, tiredness, and fluid in the lungs
Infusion-related reactions
- Symptoms of an infusion-related reaction may include one or more of the following: the skin getting hot or red (flushing), chills, fever, trouble breathing, low blood pressure, wheezing, tightening of the muscles in the chest around the airways, or a fast heartbeat. Your doctor will monitor you for infusion-related reactions
Serious bleeding
- KADCYLA can cause life-threatening bleeding. Taking KADCYLA with other medications used to thin your blood (antiplatelet) or prevent blood clots (anticoagulation) can increase your risk of bleeding. Your doctorshould provide additional monitoring if you are taking one of these other drugs while on KADCYLA. Even when blood thinners are not also being taken, life-threatening bleeding may occur with KADCYLA
Low platelet count
- Low platelet count may happen during treatment with KADCYLA. Platelets help your blood to clot. Signs of lowplatelets may include easy bruising,bleeding,and prolonged bleeding from cuts.In mild cases there may not be any symptoms
Nerve damage
- Symptoms may include numbness and tingling, burning or sharp pain, sensitivity to touch, lack of coordination, muscle weakness, or loss of muscle function. Your doctor will monitor you for symptoms of nerve damage
Skin reactions around the infusion site
- KADCYLA may leak from the vein or needle and cause reactions such as redness, tenderness, skin irritation, or pain or swelling at the infusion site. If this happens, it is more likely to happen within 24 hours of the infusion
What are the most common side effects of KADCYLA?
The most common side effects in people taking KADCYLA for early breast cancer are:
- Tiredness
- Nausea
- Liver problems
- Pain that affects the bones, muscles, ligaments, and tendons
- Bleeding
- Low platelet count
- Headache
- Weakness, numbness, and pain in the hands and feet
- Joint pain
The most common side effects seen in people taking KADCYLA for metastatic breast cancer are:
- Tiredness
- Nausea
- Pain that affects the bones, muscles, ligaments, and tendons
- Bleeding
- Low platelet count
- Headache
- Liver problems
- Constipation
- Nosebleeds
You are encouraged to report side effects to Genentech and the FDA. You may contact Genentech by calling1-888-835-2555. You may contact the FDA by visitingwww.fda.gov/medwatchor calling1-800-FDA-1088.
Talk to a healthcare professional for more information about the benefits and risks of KADCYLA.
Please seefull Prescribing Informationfor Important Safety Information, including most serious side effects.
If you cannot afford your medication, visitgenentech-access.com/patientfor financial assistance information.
